Down regulated in adenoma

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August undefined, 2024

WebNov 1, 2010 · Background The Down Regulated in Adenoma (DRA) encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel ... WebAug 7, 2024 · The chloride/bicarbonate exchanger SLC26A3 (down-regulated in adenoma, DRA) is expressed mainly in colonic epitheli-um where it dehydrates the stool by facilitating the final step of chloride and...

Segmental differences in Slc26a3-dependent Cl

Protein DRA is a membrane protein in intestinal cells. It is an anion exchanger and a member of the sulfate anion transporter (SAT) family. It mediates chloride and bicarbonate exchange and additionally transports sulfate and other anions at the apical membrane, part of the plasma membrane of enterocytes. It … See more Chloride anion exchanger, also known as down-regulated in adenoma (protein DRA), is a protein that in humans is encoded by the SLC26A3 gene. See more Mutations in this gene have been associated with congenital chloride diarrhoea, a treatable disease. The congenital absence of this membrane protein results in an See more • Solute carrier family See more • Sandal NN, Marcker KA (January 1994). "Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor". Trends in … See more WebAug 6, 1999 · Mouse Down-regulated in Adenoma (DRA) Is an Intestinal Cl−/HCO3 − Exchanger and Is Up-regulated in Colon of Mice Lacking the NHE3 Na+/H+Exchanger*. … is jersey shore family vacation on hulu

All-trans-retinoic Acid Increases SLC26A3 DRA (Down-regulated …

WebMay 1, 2007 · Consistent with in vitro data, phosphorylated PKCμ was significantly up-regulated in the tumors. We conclude that down-regulation of the D2R in APA plays an important role in the pathogenesis of PA. Subjects and Methods Experimental subjects. The diagnosis of APA was established by the clinical manifestations of PA and confirmed … WebPubMed WebSep 15, 2024 · As a result, TEP lncRNA ROR was down-regulated while upregulated in tumor tissues, promoting progression and metastasis of NPC. A posterior rhinoscopy or endoscopy biopsy helps with the diagnose of NPC, however, the information acquired from a single biopsy is limited, and the invasiveness of this operation caused a limitation for … kevin scott christian

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Mouse Down-regulated in Adenoma (DRA) Is an Intestinal …

WebAug 11, 2008 · Mouse down-regulated in adenoma (DRA) is an intestinal Cl − /HCO 3 − exchanger and is up-regulated in colon of mice lacking the NHE3 Na + /H + exchanger. J Biol Chem. 1999; 274 : 22855-22861 Crossref WebAug 7, 2008 · SLC26A3, also known as down-regulated in adenoma (DRA), normally exhibits high rates of Cl − /HCO 3 − exchange, and loss-of-function mutations of SLC26A3 are responsible for the human genetic disease congenital Cl − losing diarrhea (CLD). 8 – 10 SLC26A6, also known as PAT-1, is a robust Cl − /HCO 3 − exchanger but also … kevin scott keyes obituaryWebAll-trans-retinoic acid (ATRA) is an active vitamin A derivative known to modulate a number of physiological processes, including growth and development, differentiation, and gene transcription.The protective effect of ATRA in gut inflammation and diarrheal diseases has been documented. In this regard, down-regulated in adenoma (DRA, a key luminal … kevin scott lewis facebook louisville ky

"WebJun 10, 2014 · Dkk1 expression was down-regulated during the colorectal adenoma-carcinoma sequence, both among the 476 samples and in the 46 sets of matched specimens. Dkk1 expression was correlated with ... " - Down regulated in adenoma

Down regulated in adenoma

Clinicopathological significance of caspase-8 and caspase-10 …

WebMutations in human DRA cause congenital chloride diarrhea, thereby raising the possibility that it functions as a Cl−/HCO3− exchanger. To test this hypothesis we cloned a cDNA encoding mouse DRA (mDRA) and analyzed its activity in cultured mammalian cells. When expressed in HEK 293 cells, mDRA conferred Na+-independent, electroneutral … WebJan 25, 2016 · The aberrant expression of transcription factor Basonuclin (BNC) had been reported in different kinds of tumors. Here, we investigated the expression and methylation status of two Basonuclin homologs, BNC1 and BNC2 in hepatocellular carcinoma (HCC). We found that the expression levels of both BNC1 and BNC2 were down-regulated in …

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WebApr 12, 2024 · The dual down-regulation of Y705-STAT3 and p65 activities has led to further increased presence of CSCs in TME-stimulated cells, demonstrating additive activities of the two transcription factors. Moreover, doxorubicin resistance studies and clinical information from the TCGA patient dataset have demonstrated the connection of …

WebOct 21, 2024 · SLC26A3 or DRA (Down Regulated in Adenoma) plays a major role in mediating Cl- absorption in the mammalian intestine. Disturbances in DRA function and expression have been implicated in intestinal ... WebMar 1, 2002 · The recently discovered dra (down-regulated in adenoma) gene encodes a transport protein (DRA) for SO 4 2−, Cl −, and HCO 3 −. The aim of this study was to …

WebApr 12, 2024 · A specific heterozygous point mutation that affects the noncanonical histone H3.3 is present in 70 to 80% of DIPG tumors. This dominant somatic mutation occurs in H3-3A—one of two genes encoding identical H3.3 proteins—replacing lysine 27 with methionine (K27M).H3.3K27M is an oncogenic gain-of-function mutation that inhibits the enhancer of … WebJan 1, 2012 · Even mild ileocolonic inflammation may result in a decrease of epithelial HCOSymbol secretion, which may contribute to alterations in surface pH, intestinal flora, and mucus barrier properties. Background: Ileocolonic luminal pH has been reported to be abnormally low in inflammatory bowel disease (IBD) patients, and one of the causative …

WebNov 1, 2008 · @article{Walker2008DownregulatedIA, title={Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.}, author={Nancy M. Walker and Janet E. Simpson and Pei-Fen Yen and Ravinder Kaur Gill and Elizabeth V Rigsby and Jennifer M. Brazill and Pradeep K. Dudeja and …

WebMethods and results: We examined Dkk1 expression immunohistochemically in 476 colorectal tissue samples, including 46 sets of matched specimens. Dkk1 expression … is jersey shore family vacation on netflixWebNov 1, 1996 · By refined genetic and physical mapping4,5, a cloned gene having anion transport function, Down-regulated in adenoma (DRA)6–8, was implicated as a … kevin scott chester nhWebMay 1, 2024 · Request PDF On May 1, 2024, Balasubramanian Palaniappan and others published Mo1612: MECHANISM OF REGULATION OF DOWN REGULATED IN ADENOMA (DRA) MEDIATED ALTERATIONS IN DISTAL COLONIC CHLORIDE ... kevin scott jones fort richardson alaskaWebSep 1, 2002 · Abstract. The down-regulated in adenoma ( DRA) gene is significantly down-regulated in adenomas and adenocarcinomas of the colon as well as in colon … kevin scott coiffeur lyonWebMay 1, 2024 · Mo1612: MECHANISM OF REGULATION OF DOWN REGULATED IN ADENOMA (DRA) MEDIATED ALTERATIONS IN DISTAL COLONIC CHLORIDE … kevin scott chiropractor jackson tnWebThe effect of Shh on hormone secretion was confirmed in primary cultures of normal rat pituitaries and human pituitary tumors. Results: Ptc1 and Ptc2 were present, whereas Shh was down-regulated in pituitary adenomas and completely absent in Cushing tumors. Shh inhibited cell proliferation in AtT-20 corticotrophinoma cells and the Shh-specific ... kevin scott dds the woodlandsWebThe recently discovered dra (down-regulated in adenoma) gene encodes a transport protein (DRA) for SO42−, Cl−, and HCO3−. The aim of this study was to investigate … kevin scott hollywood sc