Ferritinophagy cargo receptor ncoa4
WebOct 5, 2015 · NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes are poorly understood. WebFeb 23, 2024 · The cytoplasm-to-vacuole targeting (Cvt) pathway is a biosynthetic autophagy-related process specific to yeast, in which vacuolar enzymes are transported from the cytoplasm into the vacuole...
Ferritinophagy cargo receptor ncoa4
Did you know?
WebMay 3, 2024 · NCOA4 is the cargo receptor of ferritin-mediated ferritinophagy, and depletion of NCOA4 could almost completely block ferritin colocalization to lysosomes (Fig. 2h, upper row; Supplementary Fig. S2h). WebFigure 6 Restoring iron homeostasis via NCOA4-mediated ferritinophagy reverse growth suppression role of PINK1 loss. A. shNT and shPINK1 cells were treated with 100 μM Ferric ammonium citrate (FAC) and proliferation was measured for 72 hours. B. ... Ferritinophagy is coordinated by the cargo receptor NCOA4, which binds to both FTL and FTH1 and ...
WebApr 28, 2024 · Ferritinophagy is the lysosome degradation of ferritin, targeted by the NCOA4 (Nuclear Receptor Coactivator 4) chaperone. DDIT4 is a potent inhibitor of mTOR, acting downstream of AKT by... WebOct 1, 2024 · Nuclear receptor coactivator 4 (NCOA4) is identified as a cargo receptor for the autophagic degradation of ferritin that is known as ferritinophagy, and NCOA4 …
WebMar 24, 2024 · When free iron levels are high, iron is stored as Fe 3+ in ferritin, which can undergo ferritinophagy, i.e., autophagic degradation of ferritin via nuclear receptor coactivator 4 (NCOA4, a cargo-binding protein), which releases iron into the cytosol as Fe 2+ and contributes to the LIP. HERC2 is an E3 ubiquitin ligase for NCOA4 that promotes … WebApr 12, 2024 · NCOA4 is a selective cargo receptor in ferritinophagy. NCOA4 finely regulates cellular iron homeostasis by anticipating the autophagic degradation of ferritin. Under iron-replete cellular conditions, HERC2-mediated ubiquitylation facilitates the …
WebDec 2, 2016 · Under low iron conditions, nuclear receptor coactivator 4 (NCOA4) protein accumulates and promotes, as cargo receptor, ferritinophagy. We have recently demonstrated that mice carrying genetic ablation of NCOA4 were unable to mobilize iron from deposits, featuring tissue iron overload as well as mild anemia.
WebApr 11, 2024 · Introduction. Ferroptosis is a non-apoptotic, iron-dependent form of cell death characterized by the accumulation of lipid peroxides. 1 Its foundation is active iron, which can be produced through the ferritinophagy pathway. 2 Ferritinophagy is a new type of autophagy that relies on the nuclear receptor coactivator 4 (NCOA4), a receptor that … extended sm64 romWebMay 28, 2014 · Like known cargo receptors, NCOA4 was highly enriched in autophagosomes, and associated with autophagy-8 (ATG8)-related proteins that recruit cargo-receptor complexes into autophagosomes (see, e.g., GABARAPL2, 607452 ). Unbiased identification of NCOA4-associated proteins revealed ferritin heavy chain (see … buchanan swim and diveWebAbstract. Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage … extended snap benefits in ohioWebOct 23, 2024 · Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage complex, in a … extended sliding car seatWebOct 14, 2024 · Mechanistically, autophagy receptor SQSTM1/p62 acts as a platform to promote the interaction between NCOA4 and LC3, thus promoting ferritin degradation to enhance ferroptosis sensitivity, this process is regulated by USP8 . The suppression of USP8-SQSTM1-NCOA4-ferritin axis through up-regulating ferritinophagy and … buchanans whiskeyWebNCOA4 Mediates Ferritinophagy and Regulates Intracellular Bioavailable Iron. We recently identified NCOA4 as the selective autophagy receptor mediating delivery of iron-laden ferritin to the lysosome for degradation … buchanans whiskey 18 priceWebMay 21, 2024 · Nuclear receptor coactivator 4 (NCOA4) is the selective cargo receptor that can bind ferritin and deliver it to autophagosome, leading to the selective autophagy of ferritin, ... Although the NCOA4-mediated ferritinophagy plays a positive role in the proliferating DPSCs, the potential detrimental effect of ferritinophagy in MSCs-based ... buchanans whiskey 12 price