WebJul 28, 2011 · Fig. 2 FI6 binds and neutralizes group 1 and group 2 influenza A viruses. ( A) Antibody binding (EC 50 ELISA values) to recombinant or purified HAs … Web0.015M Potassium Phosphate Buffer, pH 7.2 with 0.85% Sodium Chloride. Specificity. 6-Carboxyfluorescein. Storage and Shipping. Storage. Short Term: 2-8°C. Long Term: …
Production and stabilization of the trimeric influenza ... - PNAS
WebUsing a single-cell culture method for screening large numbers of human plasma cells, we isolated a neutralizing monoclonal antibody that recognized the hemagglutinin (HA) glycoprotein of all 16 subtypes and neutralized both group 1 and group 2 influenza A viruses. Passive transfer of this antibody conferred protection to mice and ferrets. WebFeb 7, 2024 · FI6 is a well-known, broadly IAV-reactive human monoclonal antibody . The expression plasmids of the V H and L H gene of the FI6-IgG antibody were constructed … optima dairy investment
A non-neutralizing antibody broadly protects against …
WebApr 24, 2024 · FI6 is the first proven such monoclonal antibody to bind to H1–H16 and is protective in mice and ferrets. Multiple studies have shown that Fc-dependent mechanisms are essential for FI6 in vivo efficacy. WebIn the past decade, a number of human monoclonal antibodies have been described that can bind to and neutralize a broad range of influenza A and B viruses. Most of these monoclonal antibodies are directed against the viral hemagglutinin (HA) stalk and some have now been evaluated in early to mid-stage clinical trials. WebJan 7, 2024 · In this study, characterization of the functional properties of IgG, monomeric IgA, and polymeric IgA antibody clones F11, FI6 (an anti-HA stalk-binding clone) , and … optima d35 yellow top battery