Phosphopantetheine binding acp domain

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August undefined, 2024

WebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present acyl substrates to a... WebJun 2, 2011 · Introduction. One of the most distinctive features of fatty acid, nonribosomal peptide and polyketide biosynthetic pathways is the utilization of the acyl carrier protein (ACP) or peptidyl carrier protein (PCP) for the shuttling of biosynthetic intermediates among various catalytic domains or proteins –.The small and highly dynamic ACPs or PCPs can …

Phosphopantetheine - an overview ScienceDirect Topics

WebOct 5, 2001 · B. subtilis AcpS and its substrate ACP were biochemically characterized. AcpS also modified the d-alanyl carrier protein but failed to recognize PCP and an acyl carrier … WebMar 2, 2010 · 7 malonyl-CoA + hexanoyl- [acyl-carrier protein] = 7 CoA + norsolorinate anthrone + [acyl-carrier protein] + 7 CO (2) + 2 H (2)O. Biochemical function: not assigned. … grace bros nursery

Phosphopantetheine - an overview ScienceDirect Topics

http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 WebAn object of the present invention is to provide a microorganism that efficiently produces EPA and a method for producing EPA using the microorganism. The present invention relates to a microorganism having an ability to produce docosahexaenoic acid (DHA), wherein the microorganism contains a protein composed of an amino acid sequence in … WebJan 12, 2024 · Phosphopantetheine binding ACP domain (Q24722578) InterPro Domain PP-bd_ACP IPR009081 edit Statements instance of protein domain 1 reference subclass of … grace brought me through

The Crystal Structure of a Mammalian Fatty Acid Synthase

Phosphopantetheine - an overview ScienceDirect Topics

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … WebNov 20, 2024 · Fatty acid and phospholipid metabolism Other PAO1 genes in this class Pathways Functional Predictions from Interpro Search for additional functional domains at the NCBI CDD database website. Go to this protein's … grace brothers removals coventryWebJul 22, 2015 · Acyl carrier protein (ACP) Phosphopantetheine binding ACP domain; Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule ... Sequence domains: Phosphopantetheine attachment site. Ligands and Environments No bound ligands. No modified residues. grace brothers nursery north royalton ohio

"WebSep 29, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and … " - Phosphopantetheine binding acp domain

Phosphopantetheine binding acp domain

Structural and binding studies of phosphopantetheine …

WebNov 20, 2024 · Phosphopantetheine binding ACP domain 2710 2771 2.6E-13 SUPERFAMILY SSF52777 CoA-dependent acyltransferases -- 3253 3430 2.22E-46 Pfam PF13193 AMP … Web210-kDa -chain contains a KS domain, a ketoacyl reductase (KR), and a phosphopantetheine transferase domain. In addi-tion, the -chain includes an N-terminal ACP, required for the …

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WebView Lecture_set+5+lipid+synthesis+notes.pdf from CHEM 153C at UCLA Community School-Los Angeles. The input to fatty acid synthesis is acetyl-CoA, which is carboxylated to malonyl-CoA. The WebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to …

WebApr 10, 2024 · HIGHLIGHTS. who: Filamentous Fungi and collaborators from the National Cheng Kung University, Taiwan have published the research work: Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi, in the Journal: (JOURNAL) how: This Tet-On system was applied with A. fumigatus for inducible expression of the gene of … WebWelcome to PomBase A comprehensive database for the fission yeast Schizosaccharomyces pombe, providing structural and functional annotation, literature curation and access to large-scale data sets Gene summary Gene standard name lys1 Systematic ID SPAP7G5.04c Product aminoadipate-semialdehyde dehydrogenase …

WebJul 10, 2024 · Acyl carrier proteins (ACPs) involved in fatty acid and polyketide synthesis, our main interest here, carry an acyl group attached to the ppt arm via a thioester linkage. …

WebMar 1, 2002 · Furthermore, the helical structure of ACP resembles that of 14-3-3, which suggests that this region of the enzyme may be important in ACP recognition and binding. Therefore, it is likely that the AHL synthase binds acyl-ACP first, followed by a conformational rearrangement of the N-terminal domain and SAM binding in a bi-ter …

WebMar 2, 2010 · Phosphopantetheine binding ACP domain Structure analysis Details Assembly composition: monomeric ( preferred) Entry contents: 1 distinct polypeptide molecule Macromolecule: Norsolorinic acid synthase Molecule details › Chain: A Length: 89 amino acids Theoretical weight: 9.43 KDa Source organism: Aspergillus parasiticus grace brown attorneyWebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond (Crawford et al. 2008; Meier et al. 2010; ... grace brown aprn ctWebJul 5, 2024 · Sequence domains: Thioester reductase-like domain; ACP-like superfamily; Phosphopantetheine binding ACP domain; AMP-dependent synthetase/ligase domain; … grace brow designWebPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). [1] grace brown brown harris stevensWebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. Catalytic activity acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP+ 3 publications chili\u0027s reading massWebJul 10, 2024 · ACP3 is a four-helix bundle with S38 being unmodified in the apo form of the protein, phosphopantheine bound in the holo form, and with polyketide substrate attached to the phosphopantetheine in the acyl bound form. The protein backbone is shown as ribbon, with the S38 side chain and bound substrate shown as atoms with standard CPK colorings. chili\\u0027s redding caWebChr: 1 Mapping Details/Browsers Description Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. … chili\u0027s reading pa